NoduleRisk

NoduleRisk is a clinical decision support tool for physicians evaluating pulmonary nodule malignancy risk. It computes probability estimates and management guidance across five validated models simultaneously. MODELS INCLUDED • Mayo Clinic (ACCP) — logistic regression model for incidentally detected nodules • Brock (BTS/PanCan) — recommended for screening populations; validated in the Pan-Canadian Lung Cancer Screening Study • Herder (BTS) — incorporates FDG-PET/CT uptake when available • BIMC (Bayesian) — Bayesian likelihood ratio model with adjustable prior probability; displays individual likelihood ratio contributions • Fleischner 2017 — guideline-based follow-up recommendations with automatic risk stratification FEATURES • Multi-nodule evaluation (up to 6 nodules per patient) • Volume doubling time calculation from serial CT measurements • Risk-stratified management recommendations for each model • Applicability warnings when inputs are outside model validation ranges • Clinical context adjustments for screening and biopsy-referred populations • Fully offline — no data is transmitted or stored IMPORTANT NoduleRisk is intended for use by qualified clinicians as a decision support aid only. Results must be interpreted in the context of the full clinical picture and do not substitute for institutional guidelines, multidisciplinary team discussion, or clinical judgment.